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There is the rather standard "believe in yourself and you can do anything" message, but this is not empty self-esteem BS. Our Panda hero Po actually has to work and train hard to harness his inborn talent to achieve something worthwhile, and his teacher Master Shifu manages to adjust his teaching methods to accomodate how his student learns. These are lessons that would greatly enrich our real lives.
Oh yeah, each of us in my party laughed our heads off during the entire movie. Get up and go already while it's still in theaters.